MXenes have attracted great attention due to their multifunctional properties and abundant surface terminations. However, it remains a considerable challenge to construct MXene hydrogels with high toughness and long-term sensory performance to withstand harsh environments. Herein, a multifunctional conductive organohydrogel based on 2D MXene nanosheets and ZA fibers were fabricated and then assembled wireless wearable sensors to track human movement. By introducing ternary mixture, the organohydrogels possess ultra-low temperature resistance (−81 °C) and moisture retention. Simultaneously, the interaction of alginate chains induced by Zn ions with PAM endows the organohydrogels with superior mechanics. Amazingly, the hydrogel sensor exhibited the highest pressure sensing performance (S_p1 = 782.7 kPa⁻¹) and harsh-environment tolerance. Importantly, zinc-activated MXene nanosheet endowed the resultant with the favorable antibacterial ability and serves in organohydrogels for potential medical applications. This method provides a facile approach for designing sustainable dual-mode sensors with high toughness, antibacterial performance, all-weather availability, and wireless transmission.